2nd Annual Biomarkers in Diagnostics & Therapeutics 2012

Conference: 25 Apr 2012 – 26 Apr 2012, Singapore. Organized by Event Protocol.
nanotechweb.org: events

Seeing biomarkers with the naked eye

“Plasmonic Fano resonances” help in early detection of cancer biomarkers
nanotechweb.org: tech update

Nanoparticle Enhanced Imaging: Emerging Oncologic Applications: Book Edition of Cancer Biomarkers

Product Description
Nanotechnology refers to the research and technical development of objects in a scale range of 1 to 100 nanometers. Particles that are nano-sized are opening new research avenues in the field of engineering and life sciences. Imaging with biocompatible nanoparticles has emerged as one of the most promising new diagnostic imaging technology fulfilling the goal of developing cost-effective magnetic nanoparticles with acceptable targeting efficiency, favorable pharmacokinetics and a good safety profile. These nanoparticles target the reticuloendothelial system and this combined with unique properties of superparamagnetism allows them to be used as excellent probes for magnetic resonance imaging (MRI). Nanoparticle Enhanced Imaging: Emerging Oncologic Applications focusses on the use of a specific type of magnetic nanoparticle (ferumoxtran-10) to overcome imaging handicaps in cancer staging as well as discuss emerging applications of newer magnetic nanoparticles. Imaging with ferumoxtran-10 offers the potential of staging tumors at stages much earlier than those detectable today.

IOS Press is an international science, technical and medical publisher of high-quality books for academics, scientists, and professionals in all fields.

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Mitochondria and Cancer

Product Description

The book begins with a general overview of Warburg Hypothesis, mitochondrial structure and function, and then outline more specifically the metabolic and molecular alterations in mitochondria that are associated with human cancer and their clinical implications. An emphasis is also placed on mtDNA mutations and their potential role in carcinogenesis. The potential use of mitochondria as biomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents will also be discussed.

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Harvard University and Nanosys License Nanowire Biosensor Systems to Vista Therapeutics

Harvard University’s Office of Technology Development (OTD), Nanosys, Inc., and Vista Therapeutics, Inc. today announced that Vista has signed License Agreements with both Harvard University and Nanosys covering several patents and patent applications related to the use of nanowires for biosensors.

The core intellectual property (IP) involves a wide range of applications in nanotechnology, nanomaterials and the use of nanowire-based field effect transistors (FETs) as biosensors, all of which were derived from the work of Dr. Charles Lieber, a professor of Chemistry at Harvard, and a pioneer in nanotechnology.

Under terms of the agreements, Vista has secured the exclusive, worldwide rights for the use of nanowires for detection of biomarkers associated with organ or tissue damage, and any form of treatment or therapeutics-associated adverse response(s). In consideration, Harvard and Nanosys have received an equity position in Vista, as well as upfront license and downstream royalty payments.

While Harvard and Nanosys each own extensive portfolios of IP around multiple aspects of nanotechnology including basic nanowire compositions, nanowire synthesis and the use of nanowires and other nanostructures for many applications, Vista will focus its attention on the use of nanowire-based FETs as highly sensitive sensors of biomolecules. The power of Lieber’s nanotechnology inventions is that they permit continuous and real-time monitoring of multiple biomarkers in blood and urine. Vista plans to manufacture and sell nanowires that are formatted to provide real-time, continuous measurement of blood and urinary biomarkers of organ and tissue injury.

“Just as EKG instruments allow physicians to continuously monitor a patient’s heart function, the broad nanowire IP portfolio acquired in these agreements will allow Vista to commercialize and market its NanoBioSensor™ platform that enables physicians, clinicians and pharmaceutical researchers to continuously monitor, on a real-time basis, a wide variety of blood and urinary biomarkers that will be transformational to patient care,” according to Dr. Spencer Farr, Founder and Chief Executive Officer of Vista.

“The potential to commercialize this portfolio of nanowire technologies is quite significant and could fundamentally reshape approaches to the monitoring of medical emergency situations,” said Isaac T. Kohlberg, Harvard University’s Senior Associate Provost and Chief Technology Development Officer. “Working together with Nanosys to license these patents to Vista, we’re able to move the technology forward and give it every opportunity to evolve from initial laboratory findings to commercial applications, which will benefit society. We’re excited to be working in concert with both companies as they grow as leaders in their respective fields.”

About Harvard University’s Office of Technology Development

The Harvard Office of Technology Development (OTD) is responsible for all activities pertaining to the evaluation, patenting and licensing of new inventions and discoveries made at Harvard University and Harvard Medical School. OTD also serves to further the development of Harvard technologies through the establishment of sponsored research collaborations with industry. OTD’s mission is to promote the public good by fostering innovation and translating new inventions made at Harvard into useful products available and beneficial to society.

About Nanosys, Inc.

Nanosys, Inc. is a leader in the development of nanotechnology enabled products utilizing high performance inorganic nanostructures. Nanosys has built one of the broadest technology platforms in the industry with over 650 patents and patent applications covering fundamental areas of nanotechnology. Based in Palo Alto, California and privately held, Nanosys collaborates with industry leaders to develop revolutionary high-value, high-performance products for life sciences, computing, optoelectronics, renewable energy, and defense. Additional information on Nanosys can be found at www.nanosysinc.com.

About Vista Therapeutics, Inc.

Vista Therapeutics, Inc. is a start-up company founded by Dr. Spencer Farr, a molecular toxicologist from Harvard and founder of Xenometrix Inc. and Phase-1 Molecular Toxicology Inc., and Charles Lieber. Vista plans to commercialize its nanowire-based biosensors to allow for continuous, real-time, simultaneous, label-free monitoring of multiple biomarkers through its NanoBioSensor™ platform. In conjunction with its corporate partners, Potentia Pharmaceuticals and ICX/Meso Systems, Vista believes it is well positioned to facilitate rapid product commercialization in a capital-efficient manner. Additional information on Vista can be found at www.vistatherapeutics.org.