A NEW CANCER THERAPY: MULTI-APPLICATION OF MULTI-WALLED CARBON NANOTUBES FOR MAGNETIC RESONANCE TEMPERATURE IMAGING GUIDED LASER INDUCED THERMAL THERAPY

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In this work multi-application, multi-walled carbon nanotubes (MWCNTs) as super MR contrast agents and Near-Infared Radiation (NIR) laser absorbers are combined with Proton Resonance Frequency (PRF) based Magnetic Resonance Temperature Imaging (MRTI) to improve the safety and efficacy of Laser Induced Thermal Therapy (LITT). Instilled MWCNTs enable precise tumor localization and killing of the tumor through preferential high temperature while protecting surrounding healthy tissue by monitoring the 3D temperature distribution. As advanced MR contrast agents (CA), Fe-containing MWCNTs produced by chemical vapor deposition (CVD) with 600mg Ferrocene, show up to 5 times greater efficiency in changing T2 relaxation properties compared to the clinical MR CA, Feridex. Thus, MWCNTs could be used potentially as a super heating generator and contrast agents in thermal ablation therapy.

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Nanomaterials and Nanosystems for Biomedical Applications

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“Nanomaterials and Nanosystems for Biomedical Applications” brings together under a single cover various aspects of functional bioengineered materials and nanostructured biomaterials including commonly used implants and sustained release nanodevices. The book includes expert reviews on the advances and current problems associated with the implants and nanodevices along with their applications in medicine, pharmaceutics, cancer therapy, gene transfer and drug delivery. The editor, M. R. Mozafari (PhD), has been working in the field of nanobiotechnology for the past 14 years and has produced more than 60 publications. The book also describes the key research parameters pertaining to major technologies employed in the field. To put it in perspective, all important aspects dealing with the chemistry, physics, biology and engineering of nanostructured biomaterials and their applications in nanobiotechnology are covered.

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Biomedical Nanostructures

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Learn to Use Nanoscale Materials to Design Novel Biomedical Devices and Applications

Discover how to take full advantage of nanoscale materials in the design and fabrication of leading-edge biomedical devices. The authors introduce you to a variety of possible clinical applications such as drug delivery, diagnostics, and cancer therapy. In addition, the authors explore the interface between micron and nanoscale materials for the development of applications such as tissue engineering. Finally, they examine the mechanisms of cell interactions with material surfaces through the use of nanotechnology-based material processing and characterization methods.

The text’s three sections highlight its interdisciplinary approach:
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Part One: Nanostructure Fabrication
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Part Two: Bio-Nano Interfaces
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Part Three: Clinical Applications of Nanostructures

Among the key topics covered are nanotechnology in tissue regeneration; biomolecular engineering; receptor-ligand interactions; cell-biomaterial interactions; nanomaterials in diagnostics, drug delivery, and cancer therapy; and nano- and micron-level engineering and fabrication.

Throughout the text, clear examples guide you through the chemistry and the processing involved in designing and developing nanoscale materials for biomedical devices. Each chapter begins with an introduction and ends with a conclusion highlighting the key points. In addition, references at the end of the chapter help you expand your research on any individual topic. In summary, this book helps biomedical researchers and engineers understand the physical phenomena that occur at the nanoscale in order to design novel cell-based constructs for a wide range of applications.

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Molecular Diagnostics: The Key Driver in Personalized Cancer Medicine

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Written by key leaders in their fields, this unique compilation provides a thorough explanation of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. Journeying through definitions of the pharmacodiagnostic concept, this unique guide explores a variety of subjects, including molecular cancer diagnostics linked to therapy, diagnostic molecular techniques, current ongoing research, drug-diagnostic codevelopment, regulatory issues around pharmacodiagnostics, and future aspects within personalized cancer medicine.

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Dendrimer-Based Nanomedicine

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In recent decades, dendrimers — free-shaped synthetic macromolecules — have garnered a great deal of scientific interest due to their unique molecular nanostructure. Used in a variety of scientific applications, the use of dendrimers is now widely regarded as a safer, more precise, and more effective way to practice medicine.

This book compiles and details cutting-edge research in science and medicine from the interdisciplinary team of the Michigan Nanotechnology Institute for Medicine and Biological Sciences, who are currently revolutionizing drug delivery techniques through the development of engineered nanodevices. Edited by Istvan J Majoros and James Baker, Jr., two prominent nanotechnology researchers, this book will appeal to anyone involved in nanotechnology, macromolecular science, cancer therapy, or drug delivery research.

Contents: Targeted Drug Delivery in General, New Technology in Medicine (B B Ward & J R Baker, Jr.); General Carriers for Drug Delivery (T H Dunham et al.); Poly(amidoamine) Dendrimer Synthesis and Characterization (I J Majoros & D E Carter); Optical and Biophotonic Applications of Dendrimer Conjugate (J Y Ye & T B Norris); Dendrimer Conjugates for Cancer Treatment (I J Majoros et al.); Biological Application of PAMAM Dendrimer Nanodevices in vitro and in vivo (T P Thomas & J F Kukowska-Latallo); Dendrimer-based Targeted Apoptosis Sensors for Medical Application (A Myc et al.); MRI Using Targeted Dendrimer Contrast Agents (S D Swanson & C R Williams); Nanoparticle Membrane Interactions: Mechanism for Enhanced Permeability (S Hong et al.); Computer Simulations of Dendrimers (S K Kandasamy et al.); Dendrimer-Entrapped and Dendrimer-Stabilized Metal Nanoparticles for Biomedical Applications (X-Y Shi & S H Wang).

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