Nanotechnology in Therapeutics

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Nanotechnology is a multidisciplinary field covering a large and diverse array of devices and materials in nanometre scale, derived from engineering, physics, chemistry and biology. The field of applied nanotechnology in medicine is growing fast and the application of nanotechnology to therapeutics has led to advances in drug delivery, biomaterials, biomedical devices, intelligent processes and in many other areas of medicine and applied biomedical sciences.

The authors of this volume describe and discuss current technology and the applications of nanoparticles and nanostructures in various aspects of therapeutics and drug delivery. The chapters are completely up-to-date and are written by some of the leading scientists in the field. Topics covered include chronobiology, chronopharmacology and chronotherapeutics, polymeric gene delivery vectors, biohybrid materials, biomimetic systems, hydrogel nanocomposites, star polymers and dendrimers, ionic nanoparticulate systems, nanospheres and nanoparticles. Entire chapters are devoted to specific applications of nanotechnology such as cancer therapy, bone disorders, and diabetes.

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Cancer Nanotechnology: Methods and Protocols

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Early detection of cancer at the cellular level, even before anatomic anomalies are visible, is critical to more efficacious and cost effective diagnosis and therapeutic advances. In Cancer Nanotechnology: Methods and Protocols, an international panel of experts provide the most recent, cutting-edge, “how-to” approaches developed and employed by researchers in a variety of disciplines to identify cancer specific biomarkers, construct suitable multifunctional targeted nanostructure platforms, along with enhanced imaging and therapeutic applications. Covering such topics as multifunctional and multimodal nanoparticles, nanoparticle mediated cancer theranostics, molecular targets for cancer nanotechnology, and nanoparticles for non-invasive image-guided cancer therapy, the volume addresses the key challenges of the field today, specifically targeted and localized delivery of the drugs. As a volume in the highly successful Methods in Molecular Biology™ series, the protocols chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Cancer Nanotechnology: Methods and Protocols integrates cancer biology, clinical oncology, molecular cancer imaging, materials science and chemical engineering, biomedical engineering, toxicology, computer science, electrical engineering, chemistry, physics, and mathematics in order to achieve the vital goals of nanotechnology-mediated early cancer detection and more efficacious and less toxic therapies for these devastating diseases.

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Nanomaterials for Cancer Therapy

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This first comprehensive overview on nanotechnological approaches to cancer therapy brings together therapeutic oncology and nanotechnology, showing the various strategic approaches to selectively eliminating cancerous cells without damaging the surrounding healthy tissue. The strategies covered include magnetic, optical, microwave and neutron absorption techniques, nanocapsules for active agents, nanoparticles as active agents, and active and passive targeting, while also dealing with fundamental aspects of how nanoparticles cross biological barriers.
A valuable single source gathering the many articles published in specialized journals often difficult to locate for members of the other disciplines involved.

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Nanotechnology for Cancer Therapy

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While simultaneous breakthroughs occurring in molecular biology and nanoscience/technology will ultimately revolutionize all of medicine, it is with our efforts to prevent, diagnose, and treat cancer that many of the most dramatic advances will occur. In support of this potential, the U.S. National Cancer Institute (NCI) established the Alliance for Nanotechnology in Cancer in 2004 and pledged $144.3 million in funding over the next five years.

Edited by one of the most dynamic pioneers in the field, Nanotechnology for Cancer Therapy focuses on those nanoscientific and nanotechnological strategies that are evolving as the most promising for the imaging and treatment of cancer. Among the various approaches considered, nanotechnology offers great possibilities for the targeted delivery of drugs and genes to tumor sites and the ultimate replacement of those chemotherapeutic agents so compromised by side effects.

Within this volume, the expertise of world-renowned academic and industrial researchers is brought together to provide a comprehensive treatise. Composed of 38 chapters, the book is divided into 7 sections that cover -

Fundamentals of targeting strategies, nanotechnology characterization for cancer therapy, and USFDA guidelines on approval of nanotechnology products

Polymeric conjugates used for tumor-targeted imaging and delivery, including imaging to evaluate therapeutic efficacy

Polymeric nanoparticle systems that emphasize biodegradable, long-circulating nanoparticles for passive and active targeting

Polymeric micellar assemblies, where sophisticated chemistry is leading to novel nanosystems that can provide efficient delivery to tumors

Dendritic nanostructures used for cancer imaging and therapy

Liposome-based delivery systems — the oldest nanotechnology method employed in cancer therapy

Other lipid nanosystems used for targeted delivery, including those that can cross biological barriers, as well as mitochondria-specific delivery

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