World Drug Delivery Congress 2011

Conference: 5 Sep 2011 – 7 Sep 2011, Singapore, Singapore, Singapore. Organized by IMAPAC.
nanotechweb.org: events

Delivery by airway: cellular uptake of nanoparticle drug carriers

Nanoparticles interact quickly with airway epithelial cells before rapid endocytosis via the clathrin pathway and subsequent exocytosis via a cholesterol dependent pathway
nanotechweb.org: lab talk

A primer on Drug Delivery Systems

The drug delivery industry has become one of the fastest emerging industries in the healthcare sector. Drug delivery refers to the delivery of pharmaceutical substances to animals or human beings. The modes of delivery can be nasal, oral or rectal. For the drugs to prove effective, it is very important to ensure that they work in a controlled manner and get distributed throughout the body in a proper way.

Targeted drug delivery occurs when the administered drugs remains active within a particular area of the body. Targeted drug delivery can prove very effective in controlling the rapid increase of cells leading to cancerous tissues.

Most recent attempts in the realm of drug delivery include

Sustained-release formulations (in which the physician administers or releases the drug over a certain period in a controlled manner) and
Advance in intended delivery (in which the administered drugs remain active only in the targeted region of the body.

New drug delivery systems hold greater promise, as they tend to lessen the manufacturing costs. In addition, they have a better targeting ability. Due to this, the patients won’t need to take high doses and so, will face minimum side-effects.

Transdermal drug delivery system, with the use of nanotechnology, can enhance the concentration and bioavailability of the drugs. Such a technology can prove to be a boon for patients suffering from Central Nervous System (CNS) or neurodegenerative disorders.

New drug delivery systems can alleviate some major concerns of the pharmaceutical industry and offer much better prospects of finding out new and better solutions for improving the current medical problems. Apart from Nanotechnology, some other drug delivery technologies are:

Sustained Release Formulations
Nano/ Micro particulate drug delivery  systems
Self-emulsifying drug delivery  systems
Intra-nasal drug delivery systems
Innovative drug delivery solutions concerning Biotech-derived products

One of the main objectives of drug development is to find drugs that will prove to be more effective in curing diseases and treating different medical conditions.

Arrowhead Lead Scientific Advisor, Dr. Mauro Ferrari and Calando Pharmaceuticals’ siRNA Drug Delivery Platform …

Arrowhead Lead Scientific Advisor, Dr. Mauro Ferrari and Calando Pharmaceuticals’ siRNA Drug Delivery Platform …
Arrowhead Research Corporation (NASDAQ:ARWR) today announced that two articles of interest to Arrowhead stockholders appeared in the Houston Chronicle this week. An article published on May 24, entitled “Minute invaders that aid the body”, reports on the revolutionary potential of gene silencing and the pioneering role of the siRNA delivery system developed by Arrowhead majority-owned subsidiary …

Read more on SYS-CON Media

Carrier-Based Drug Delivery

Product Description
Carrier Based Drug Delivery is divided into three main sections that cover major carrier systems used to deliver drugs as well as DNA. The first section describes the use of liposomes and tubules as carrier systems. The eight chapters in this section report the use of stimuli-responsive liposomes and liposome-polymer complexes in drug and DNA delivery, the application of neutral liposomes in gene transfer, and the use of niosomes in the delivery of poorly soluble drugs. The role of vesicle shape in delivery is discussed, followed by two reviews on the use of microtubules and templated nanotubes for the delivery and separation of bioactives.

The second section is devoted to the use of polymeric micelles as targetable pharmaceutical carriers, novel therapeutics in drug delivery, and endosomolytic agents for gene delivery. The section concludes with a chapter on the use of ultrasound to improve the efficiency of polymeric micelles as carriers.

The third section presents nine chapters on the use of micro- and nanoparticulate carriers in drug delivery. These chapters address methods to prepare precise micro- and nanoparticles, the utilization of lipids in peptide and protein release, and the construction of nanocontainers, either by stabilization of liposomal templates or by layer-by-layer deposition of polymers around colloidal templates. The reduction or prevention of burst release from matrices is discussed, as well as the use of mucoadhesion and mechanical adhesion for localized nasal and peroral delivery of actives.

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