Patent applications for Shrink’s stem cell research and drug discovery tool StemDisc filed

Patent applications for Shrink’s stem cell research and drug discovery tool StemDisc filed
Shrink Nanotechnologies, Inc., an innovative nanotechnology company developing products and licensing opportunities in the solar energy production, medical diagnostics and sensors, and biotechnology research and development tools businesses, announced today that patent applications for its stem cell research and drug discovery tool StemDisc have been filed.

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Chemoinformatics: An Approach to Virtual Screening

Product Description

This book is the first monograph that summarizes innovative applications of efficient chemoinformatics approaches towards the goal of screening large chemical libraries. The focus on virtual screening expands chemoinformatics beyond its traditional boundaries as a synthetic and data-analytical area of research towards its recognition as a predictive and decision support scientific discipline. The approaches discussed by the contributors to the monograph rely on chemoinformatics concepts such as:

-representation of molecules using multiple descriptors of chemical structures;
-advanced chemical similarity calculations in multidimensional descriptor spaces;
-the use of advanced machine learning and data mining approaches for building quantitative and predictive structure activity models;
-the use of chemoinformatics methodologies for the analysis of drug-likeness and property prediction;
-the emerging trend on combining chemoinformatics and bioinformatics concepts in structure based drug discovery.

The chapters of the book are organized in a logical flow that a typical chemoinformatics project would follow – from structure representation and comparison to data analysis and model building to applications of structure-property relationship models for hit identification and chemical library design. It opens with the overview of modern methods of compounds library design, followed by a chapter devoted to molecular similarity analysis. Four sections describe virtual screening based on the using of molecular fragments, 2D pharmacophores and 3D pharmacophores.

Application of fuzzy pharmacophores for libraries design is the subject of the next chapter followed by a chapter dealing with QSAR studies based on local molecular parameters. Probabilistic approaches based on 2D descriptors in assessment of biological activities are also described with an overview of the modern methods and software for ADME prediction.

The book ends with a chapter describing the new approach of coding the receptor binding sites and their respective ligands in multidimensional chemical descriptor space that affords an interesting and efficient alternative to traditional docking and screening techniques. Ligand-based approaches, which are in the focus of this work, are more computationally efficient compared to structure-based virtual screening and there are very few books related to modern developments in this field.

The focus on extending the experiences accumulated in traditional areas of chemoinformatics research such as Quantitative Structure Activity Relationships (QSAR) or chemical similarity searching towards virtual screening make the theme of this monograph essential reading for researchers in the area of computer-aided drug discovery. However, due to its generic data-analytical focus there will be a growing application of chemoinformatics approaches in multiple areas of chemical and biological research such as synthesis planning, nanotechnology, proteomics, physical and analytical chemistry and chemical genomics.

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Nanobiotechnology Molecular Diagnostics: Current Techniques and Applications

Product Description
Molecular diagnostics has evolved rapidly during the past decade and has an impact on the practice of medicine as well as many other applications including drug discovery. Advances in biotechnology have been incorporated into molecular diagnostics. There has been a distinct trend in miniaturization with development of biochips and microfluidics. This trend has continued with the development of nanotechnology. Nanotechnologies are now being applied to molecular diagnostics to refine and extend the limits of detection. As the introductory chapter on molecular diagnostics shows, there are a large number of technologies and only a fraction of these have yet been affected by the introduction of nanobiotechnology. There is a tremendous scope for further development.

This book gives an introduction to nanobiotechnology relevant to molecular diagnostics, a field that has been termed nanodiagnostics. The current state of development of nanodiagnostic technologies including nanobiochips and nanobiosensors is reviewed. Besides important applications in clinical diagnostics, the role of molecular diagnostics in drug discovery is also described.

The voluminous literature relevant to this topic was reviewed and 180 selected references are included in the bibliography. The book will be useful for those developing nanobiotechnology, clinical laboratories, researchers in molecular diagnostics and scientists involved in drug discovery in the pharmaceutical industry. Financiers of nanotechnology have a scientific interest in the new developments and this book will be a source of useful information including the development of technologies in the commercial sector.

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Advanced Semiconductor and Organic Nano-Techniques Parts I, II and III: Set

Product Description
Physical sciences and engineering, as well as biological sciences have recently made great strides in their respective fields. More importantly, the cross-fertilization of ideas, paradigms and methodologies have led to the unprecedented technological developments in areas such as information processing, full colour semiconductor displays, compact biosensors and controlled drug discovery to name a few.

Top experts in their respective fields have come together to discuss the latest developments and the future of micro-nano electronics. They investigate issues to be faced in ultimate limits such as single electron transitors; zero dimensional systems for unique properties; thresholdless lasers, electronics based on inexpensive and flexible plastic chips; cell manipulation; biosensors; DNA based computers; quantum computing; DNA sequencing chips; micro fluidics; nanomotors based on molecules; molecular electronics and recently emerging wide bandgap semiconductors for emitters, detectors and power amplifiers.

Contributions from top experts in this field
Covers a wide range of topics

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Microdrop Generation

Product Description
The applications and use of inkjet-like microfluidic drop ejectors have grown rapidly in many fields, including biotechnology, drug discovery, combinatorial chemistry, and microfabrication. Yet to date, end users and even designers of microdrop systems for scientific applications have had no books to reference on the subject. Microdrop Generation meets the needs of all those who need to understand the physics and engineering behind microdrop technology. It also contains detailed, how-to information on the practical construction, operation, troubleshooting, and fluid formulation for microdrop ejection systems. Written by a highly experienced practitioner of the art, the book is organized as a self-contained tutorial of microdrop technology ideal for those new to the field.

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