Nanomaterials and Nanosystems for Biomedical Applications

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“Nanomaterials and Nanosystems for Biomedical Applications” brings together under a single cover various aspects of functional bioengineered materials and nanostructured biomaterials including commonly used implants and sustained release nanodevices. The book includes expert reviews on the advances and current problems associated with the implants and nanodevices along with their applications in medicine, pharmaceutics, cancer therapy, gene transfer and drug delivery. The editor, M. R. Mozafari (PhD), has been working in the field of nanobiotechnology for the past 14 years and has produced more than 60 publications. The book also describes the key research parameters pertaining to major technologies employed in the field. To put it in perspective, all important aspects dealing with the chemistry, physics, biology and engineering of nanostructured biomaterials and their applications in nanobiotechnology are covered.

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Carrier-Based Drug Delivery

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Carrier Based Drug Delivery is divided into three main sections that cover major carrier systems used to deliver drugs as well as DNA. The first section describes the use of liposomes and tubules as carrier systems. The eight chapters in this section report the use of stimuli-responsive liposomes and liposome-polymer complexes in drug and DNA delivery, the application of neutral liposomes in gene transfer, and the use of niosomes in the delivery of poorly soluble drugs. The role of vesicle shape in delivery is discussed, followed by two reviews on the use of microtubules and templated nanotubes for the delivery and separation of bioactives.

The second section is devoted to the use of polymeric micelles as targetable pharmaceutical carriers, novel therapeutics in drug delivery, and endosomolytic agents for gene delivery. The section concludes with a chapter on the use of ultrasound to improve the efficiency of polymeric micelles as carriers.

The third section presents nine chapters on the use of micro- and nanoparticulate carriers in drug delivery. These chapters address methods to prepare precise micro- and nanoparticles, the utilization of lipids in peptide and protein release, and the construction of nanocontainers, either by stabilization of liposomal templates or by layer-by-layer deposition of polymers around colloidal templates. The reduction or prevention of burst release from matrices is discussed, as well as the use of mucoadhesion and mechanical adhesion for localized nasal and peroral delivery of actives.

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Nanomaterials for Medical Diagnosis and Therapy

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Following an overview of nanotechnologies for diagnostic purposes, this book goes on to look at nanoparticle-based magnetic resonance, molecular and other imaging applications, as well as the potential roles of carbon nanotubes and bionanoparticles in biomedical applications. The book’s main focus is on drug delivery systems based on nonporous and nanosize materials, solid lipid and polymeric nanoparticles, intelligent hydrogels, core-shell nanoparticles, and nanocapsules, rounded off by a discussion of their biomedical applications. The final part of this volume covers such biomedical strategies as gene therapy, synthetic gene-transfer vectors and targeted delivery.

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